Artime CA, et al. - Researchers investigated if intravenous (IV) acetaminophen, a nonopioid analgesic, has similar opioid-sparing effects after craniotomy as have already been reported after abdominal and orthopedic surgeries. Among adult patients scheduled to undergo supratentorial craniotomy for excision of a brain mass, they compared total 24-hour opioid consumption, pain scores, satisfaction with overall pain management, time to meet postanesthesia care unit discharge criteria, and incidence of opioid-related side effects between those randomized to either IV acetaminophen or placebo preincision. Although IV acetaminophen, as adjunctive therapy for craniotomy procedures, was found to be related to improved patient satisfaction regarding overall pain control but failed to demonstrate opioid-sparing impact in patients for the 24 hours after craniotomy.