Steiner JE, et al. - The frequency of abnormal scarring in patients with somatic overgrowth and sequencing-verified mutations in the PIK3CA gene was observed by the experts. In subjects with PIK3CA-related overgrowth syndromes, excessive scarring occurred frequently. Hence, the risk of abnormal scarring should be discussed preoperatively. Taking into account the activating nature of these PIK3CA variants, it was noted that the excessive scarring could be owing in part to up-regulation of the PI3K-Akt-mTOR pathway