Tobón-Arroyave SI, et al. - Among 102 periodontitis patients and 61 healthy controls, experts aspired to explore whether salivary levels of lipoxin A4 (LXA4), protectin D1 (PD1), resolvin E1 (RvE1), and maresin 1 (MaR1) could constitute a reflection of periodontal health/disease status. Using multivariate binary logistic regression models, the connection between the biomarkers with disease status was evaluated individually and adjusted for confounding. The findings of this cross-sectional case-control study showed a strong/independent link between decreased LXA4 and increased PD1/MaR1 salivary levels with periodontitis suggesting an imbalance in the specialized pro-resolving lipid mediators in periodontal disease. Also identified were interaction effects between variables of demographic predictors and salivary concentration of LXA4, PD1, and MaR1.