Salivary and serum oxidative stress biomarkers and advanced glycation end products in periodontitis patients with or without diabetes: A cross‐sectional study
Journal of Periodontology Dec 16, 2020
Altıngöz SM, Kurgan Ş, Önder C, et al. - Researchers intended to determine if there is a correlation between oxidative stress, glycation, and inflammation markers and periodontal clinical parameters in periodontitis and periodontally healthy patients with type 2 diabetes and corresponding systemically healthy controls. For this cross‐sectional study, 67 periodontally healthy (DM‐H, n = 32) and periodontitis (DM‐P, n = 35) patients with type 2 diabetes, and 54 systemically healthy periodontitis (H‐P, n = 26) and periodontally healthy (H‐H, n = 28) controls were involved. It recorded and analyzed clinical periodontal parameters, BMI, fasting glucose, hemoglobin A1c (HbA1c), along with saliva and serum 8‐hydroxy‐2'‐deoxyguanosine (8‐OHdG), malondialdehyde (MDA), 4‐hydroxy‐2‐nonenal (4‐HNE), advanced glycation end products (AGE), AGE receptor (RAGE) and high sensitivity C‐reactive protein (hsCRP) levels. Findings suggested that salivary 8‐OHdG for diabetics alone or in combination with 4‐HNE, AGE and RAGE, and salivary 8‐OHdG for systemically healthy persons alone or in combination with MDA and hsCRP, could potentially serve as non‐invasive periodontitis screening markers.
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