Pepa PA, et al. - In this study, researchers primarily compared vital sign changes prior to and after risperidone administration between Emergency Department (ED) patients presenting with alcohol intoxication and without alcohol intoxication. Secondarily, they assessed the effect of benzodiazepine co-administration with risperidone on vital signs. Findings suggested that for acute agitation in patients presenting to the ED with alcohol intoxication, oral risperidone could be a safe option.