Smit MR, et al. - As ivermectin is well tolerated up to 2000 μg/kg, researchers aimed at establishing the safety, tolerability, and mosquitocidal efficacy of 3-day courses of high-dose ivermectin, co-administered with a standard malaria treatment. in this randomised, double-blind, placebo-controlled, superiority trial at the Jaramogi Oginga Odinga Teaching and Referral Hospital (Kisumu, Kenya) including adults (aged 18–50 years) with symptomatic uncomplicated Plasmodium falciparum malaria, participants were randomly assigned (1:1:1) to receive 3 days of ivermectin 300 μg/kg per day, ivermectin 600 μg/kg per day, or placebo, all co-administered with 3 days of dihydroartemisinin-piperaquine. At both doses assessed, ivermectin was well tolerated and reduced mosquito survival for at least 28 days after treatment. Findings thus suggest that ivermectin 300 μg/kg per day for 3 days provided a good balance between efficacy and tolerability.