Stock D, et al. - In view of the link between night work with reproductive dysfunction, menstrual cycle pattern disruption, researchers investigated whether rotating night shift schedules are linked with age at menopause among a large, national cohort of shift working nurses. In this cohort study of 80,840 women from the Nurses’ Health Study 2 (NHS2), 27,456 women (34%) reached natural menopause during the follow-up. Observations suggest a modest acceleration in reproductive senescence in correlation with working rotating night shifts with enough regularity among women who may already be predisposed to earlier menopause.