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Role of gastrointestinal hormones as a predictive factor for long-term diabetes remission: Randomized trial comparing metabolic gastric bypass, sleeve gastrectomy, and greater curvature plication

Obesity Surgery Jan 08, 2021

Casajoana A, Guerrero-Pérez F, de Gordejuela AGR, et al. - In the present study, the researchers sought to compare type 2 diabetes (T2DM) remission following a gastric bypass with a 200-cm biliopancreatic limb (mRYGB), sleeve gastrectomy (SG), and greater curvature plication (GCP), and to explore whether the initial secretion of gastrointestinal hormones may predict metabolic outcomes at 5 years. There were 45 patients randomized to mRYGB, SG, or GCP with mean BMI of 39.4(1.9)kg/m2 and T2DM with HbA1c of 7.7(1.9)%. With hypoabsortive techniques like mRYGB, long-term T2DM remission is mostly achieved. The main predictors of T2DM remission at 5 years were increased secretion of GLP-1 after surgery and shorter illness duration.

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