Gil-Villa AM, et al. - Researchers assessed the role of Acetylsalicylic acid (ASA), salicylates and aspirin-triggered lipoxin (ATL) in the modulation of the oxidative and inflammatory responses induced by plasma from women with preeclampsia. For inducing oxidative and inflammatory responses on endothelial cells and U937 promonocytes, they performed probing of plasma from 14 women with preeclampsia and 17 normotensive pregnant women. They assessed the role of ATL, ASA, and salicylic acid on these events. On endothelial and U937 cells, they found TBARS and nitrotyrosine production induced by plasma from women with preeclampsia. A reduction in TBARS generation in relation to pretreatment with both ATL and ASA and a reduction in nitrotyrosine by ATL was also reported. Overall, the beneficial actions of ASA could be explained by ATL. Further inquiry on mechanisms, real effectiveness, and rational use of ASA in preeclampsia, was supported.