Role of aneuploidy screening in preimplantation genetic testing for monogenic diseases in young women
Fertility and Sterility Mar 30, 2019
Hou W, et al. - Researchers performed a retrospective cohort study to examine the value of aneuploidy screening in preimplantation genetic testing (PGT) for monogenic diseases for improving the ongoing pregnancy/live birth rate of single frozen/thawed embryo transfer (FET) cycles in young women. Analysis of 569 FET cycles was done. One hundred thirty-one FET cycles from 105 oocyte retrieval cycles in 98 patients who underwent PGT for monogenic diseases with aneuploidy screening comprised the aneuploidy screening (AS) group, while 438 FET cycles from 280 oocyte retrieval cycles in 266 patients who underwent PGT for monogenic diseases without aneuploidy screening comprised the non-AS group. Outcomes revealed significantly improved ongoing pregnancy/live birth rate in correlation to aneuploidy screening in PGT among young women carrying monogenic diseases in the first FET cycles.
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