Mallia P, et al. - This investigation was carried out to investigate if glucose concentrations were increased in airway samples (nasal lavage fluid, sputum, and bronchoalveolar lavage fluid) from patients with stable chronic obstructive pulmonary disease (COPD). Furthermore, the impacts of viral infection on sputum glucose concentrations and how airway glucose concentrations relate to bacterial infection were determined herein. Findings demonstrated that patients with stable COPD had increased concentrations of airway glucose, which further increased during COPD exacerbations. In both stable and exacerbated COPD patient groups, a possible contribution of increased airway glucose concentrations to bacterial infections was suggested in this work. These data are crucial as concerning the development of nonantibiotic therapeutic strategies for the prevention or treatment of bacterial infection in patients with COPD.