Allodji RS, et al. - Using 36 colorectal cancer (CRC) cases and 140 controls selected from 7,032 five-year survivors of the French Childhood Cancer Survivor Study (FCCSS) cohort treated from 1945 to 2000 in France, researchers conducted a nested case–control study to quantify how radiation therapy and chemotherapy agents are used in the occurrence of subsequent CRC. After radiation dose (even < 30 Gy), the risk of subsequent CRC was significantly increased. In survivors of childhood cancer, this novel finding supports the need to update monitoring guidelines for CRC to optimize long-term follow-up for subsequent CRC.