• Profile
Close

Risk of pancreatic cancer for ATM variant carriers

JAMA Nov 24, 2021

Hsu FC, Roberts NJ, Childs E, et al. - In this study, the lifetime risk of pancreatic cancer was found to be elevated in persons carrying a germline pathogenic ATM variant. Such persons may benefit from enhanced early detection surveillance.

  • This is a multicenter cohort study of 2,227 family members (mean age [SD], 58 [22] years; 1,096 [49%] women) of 130 pancreatic cancer kindreds, to estimate age-specific penetrance of pancreatic cancer in people with a pathogenic variant in the ATM gene.

  • In participants with a pathogenic variant in the ATM gene, the risk of pancreatic cancer was estimated to be 1.1% by age 50 years, 6.3% by age 70 years, and 9.5% by age 80 years.

  • Among ATM variant carriers, the relative risk of pancreatic cancer was estimated to be 6.5 (95% CI, 4.5-9.5) vs noncarriers.

Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay