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Risk of myocardial infarction with use of selected non-steroidal anti-inflammatory drugs in patients with spondyloarthritis and osteoarthritis

Annals of Rheumatic Diseases May 09, 2018

Dubreuil M, et al. - Experts ascertained the risk of myocardial infarction (MI) among patients with spondyloarthritis (SpA) who were prescribed non-steroidal anti-inflammatory drugs (NSAIDs) and compared the pattern of risk in SpA vs in osteoarthritis (OA). A conditional logistic regression was conducted to compare the odds of current or recent NSAID use relative to the remote use of any NSAID, focusing on diclofenac and naproxen specifically. Results suggested an increased risk of MI in SpA among current users of diclofenac, but not naproxen. Compared to that in OA, the MI risk with diclofenac in SpA seemed to differ.

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