Fleischman AN, Li WT, Luzzi AJ, et al. - This research was sought to evaluate if prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs) following joint arthroplasty was correlated with a higher risk of gastrointestinal bleeding. Researchers conducted a retrospective study by assessing 28,794 adults who had joint arthroplasty with one of 50 surgeons from 2016-2018. There was no association between NSAIDs and gastrointestinal bleeding and NSAIDs can be prescribed safely for most patients after joint arthroplasty, as patients taking NSAIDs had lower odds of gastrointestinal bleeding. Anticoagulants, antiplatelet agents, and, to a lesser extent, aspirin, were linked with gastrointestinal bleeding. According to the results, patients who were significantly older (71.3 vs. 67.0 years), needed longer hospitalizations (2.1 vs. 1.5 days), and had a history of peptic ulcers were more likely to experience gastrointestinal bleeding