Risk of first and recurrent serious infection in sarcoidosis: A Swedish register-based cohort study
European Respiratory Journal May 10, 2020
Rossides M, Kullberg S, Eklund A, et al. - Researchers investigated whether sarcoidosis is related to a higher rate of serious infections (SI) and if this differs by age, gender, time since diagnosis, or treatment status around diagnosis. They compared people encountering sarcoidosis (≥ 2 ICD codes in the Swedish National Patient Register 2003–2013; n = 8,737) vs general population comparators matched 10:1 on age, gender, and residential location (n = 86,376). They noted that in sarcoidosis vs the general population, the rate of SI was 1.8-fold increased. A higher adjusted hazard ratios was observed in females vs males and during the first 2 years of follow-up. Overall, findings revealed a more common prevalence of SIs in sarcoidosis vs in the general population, especially during the first few years post-diagnosis. Patients who required immunosuppressant therapy around diagnosis were identified to be twice as likely to experience a serious infection compared with those who did not.
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