Jung YS, Kim NH, Kim Y, et al. - An increased risk of metachronous colorectal neoplasia (CRN), but not of metachronous advanced CRN (ACRN), was observed in correlation with proximal adenoma, yielding support for the current guidelines recommending that for distal and proximal adenoma, the same surveillance interval should be followed without discrimination by adenoma location.

• Analysis of data from 9,710 patients who underwent follow-up colonoscopy after adenoma removal.

• Relative to patients with distal only adenomas, patients with proximal only adenomas were at higher risk of metachronous CRN.

• Among patients aged < 50 years, those with proximal only non-advanced adenomas (NAAs) were at higher risk of metachronous CRN than those with only distal NAAs.

• Among patients aged ≥ 50 years, those with proximal only advanced adenomas (AAs) were at higher risk than those with distal only AAs.

• Patients aged < 50 and ≥ 50 years did not differ in the risk of metachronous ACRN based on adenoma location.