Khan UA, Fallah M, Sundquist K, et al. - Using data from several nationwide registers for all people born in Sweden since 1931 and their parents, researchers sought to determine how many years earlier than the general population patients with diabetes with/without a family history of colorectal cancer (CRC) reach the threshold risk at which CRC screening is recommended to the general population. Men with diabetes reached 0.44% risk at age 45 (5 years earlier than the recommended age of screening); the risk advancement was 4 years in women with diabetes. The risk was more pronounced for those with additional CRC family history (12–21 years earlier depending on sex and benchmark starting age of screening). The population level of risk was reached 1 to 2 decades earlier for patients with both diabetes and a family history of CRC vs the general Swedish population. This research is the first one that provides novel evidence-based information for risk-adapted starting ages of CRC screening for patients with diabetes, who are at higher risk of early-onset CRC vs the general population. The evidence-based results propose a novel risk group who may benefit from earlier initial screening irrespective of disparity and uncertainty regarding the optimal age of screening for average-risk individuals globally.