Ling Q, et al. - This study entailed an evaluation of the evidence of a link between islet autoantibodies and the development of type 1 diabetes mellitus (T1DM) in a pooled population of both genetically at-risk individuals and general people without definite genetic background. In this work, a link was established between the seroconversion of islet autoantibodies and T1DM progression in nondiabetic people with or without definite genetic susceptibility. This yielded further proof for an extensive application in routine clinical practice to identify individuals at risk of T1DM.