Rosenthal DG, Cheng RK, Petek BJ, et al. - Researchers examined how left ventricular ejection fraction (LVEF) associates with the risk of ventricular arrhythmias (VA), heart transplantation, and death in cardiac sarcoidosis (CS). One hundred and ten CS patients with baseline LVEF < 35% (n = 32) or ≥ 35% (n = 78) were identified. Over a follow-up of 2.6 (range 1.0 to 5.8) years, VA/sudden cardiac death (SCD) was reported in 49 (44.5%) CS patients; these included 19 of 32 (59.4%) with LVEF < 35%, and 30 of 78 (38.5%) with LVEF ≥ 35%. After adjustment, they identified an increased risk of VA/SCD in significant correlation with LVEF < 35% vs LVEF ≥ 35%. Per findings, high rates of VA, SCD, and heart transplantation are reported in patients with CS, even when LVEF is mildly impaired or normal. They emphasize investigating all patients with CS for arrhythmia risk, even in the setting of an otherwise reassuring LVEF.