Horton SA, Hoyt BW, Zaidi SMR, et al. - This study was carried out to ascertain whether factors can be distinguished that are correlated with treatment failure after operative management of deep surgical site infection. Between March 2006 and December 2015, researchers retrospectively examined the billing system at a Level I trauma center. They distinguished 451 patients treated for deep surgical site infection after fracture fixation at our center. They further conducted a multivariate regression analysis to assess for factors correlated with treatment failure. After deep surgical site infection, treatment failure was relatively common. It was shown that three distinct factors (polymicrobial infection, removal of implants, and IIIB/C fracture) were correlated with failure to eradicate the infection in the first series of surgeries and antibiotics. It has been considered that these findings might help guide clinicians as they counsel patients on the risk of treatment failure and might focus efforts to improve treatment toward patients at higher risk of treatment failure.