Silva MF, et al. - Risk factors for tooth loss in an extended age group of adults were determined over 4 years in this prospective cohort study. The study sample included adults (aged 20–64 years), assessed in 2011 and 2015, from Piracicaba, São Paulo, Brazil. Researchers used the index of decayed, missing, and filled teeth (DMFT), the Community Periodontal Index according to the World Health Organization, and visible biofilm to perform the home oral examination. A presence incidence of tooth loss, which was assessed by the difference between Missing teeth (M > 0) from DMFT in 2011 and that in 2015, was evaluated as the outcome. Risk factors for tooth loss in adults included age, reason for seeking dental services by pain, previous tooth loss, and decayed teeth. These risk factors supported previous research suggesting that progression and accumulation of the need for cavity treatments result in tooth loss and, hence, could be avoided.