Jankovic SM, et al. – The goal of this current investigation was to determine risk factors for each severity–based category of potential drug–drug interactions (DDIs) encountered at intensive care unit (ICU) patients. Findings reported a high rate of the DDIs in ICU patients at a tertiary care hospital, which was adversely affected by number of drugs or drug groups prescribed per patient, antiarrhythmic or anticonvulsant drug prescription, comorbidities, length of hospitalization and surgery. In addition, the presence of cognitive deficit and transfer from emergency department to ICU were found to be protective for ICU patients against the DDIs.