Lee JJ, Thompson ZS, Piccirillo JF, et al. - In this retrospective cohort study involving 147 patients (mean [SD] age, 54 [15] years; 79 women [54%]) with primary sellar lesions who had endoscopic transsphenoidal hypophysectomy (ETSH), researchers evaluated the independent prognostic role of demographic, comorbidity, cephalometric, intraoperative, histological, and postoperative parameters in patient-reported postoperative olfactory dysfunction, and analyzed the correlation between anatomical measurements of the skull base and sinonasal cavity and postoperative olfactory dysfunction. The authors discovered that clinically important risk factors for patient-reported postoperative olfactory dysfunction tended to be abdominal fat grafting, acute skull base angle, and smoking history. Increased time after ETSH can be correlated with improved olfactory results.