Martin-Loeches I, et al. - Researchers investigated risk factors for mortality in elderly and very elderly critically ill patients with sepsis. Participants were 1490 patients with ≥ 65 years of age, 1231 (82.6%) had a cardiovascular failure. The mean age [± standard deviations (SD)] was 74.5 (± 5.6) years, and 876 (58.8%) were male. Two cohorts were defined: elderly: 65–79 years and very elderly: ≥ 80 years. Higher hospital mortality was observed among patients aged 80 or over vs patients between 65 and 79 years. In the group of elderly patients, Acute Physiology Chronic Health Evaluation II (APACHE II) score of the disease, patient location at sepsis diagnosis, development of acute kidney injury, and thrombocytopenia were identified to be independently associated with mortality. Age, APACHE II score, and prompt adherence of the resuscitation bundle were identified as predictors of hospital mortality in the group of very elderly patients. Only in the very elderly group, age was identified as an independent risk factor. A reduction in hospital mortality was observed in relation to prompt therapy provided within the first 6 h of resuscitation in the very elderly patients.