Risk factors for kidney dysfunction with the use of gentamicin in open fracture antibiotic treatment
Journal of Orthopaedic Trauma Oct 25, 2018
Folse J, et al. - Researchers assessed all patients who got gentamicin to treat open fracture and ascertained the incidence of and risk factors for kidney injury in these patients. They conducted a retrospective chart review of patients who got gentamicin for open fracture antibiotic treatment from January 2008 to December 2012. Risk of kidney injury while receiving gentamicin was seen in females and heavier individuals. In patients who got gentamicin for open fracture treatment, they noted a strong association of ICU admission and concurrent CT contrasted imaging with a kidney injury. In those >60 years of age, gentamicin should not be used. Moreover, they noted a sharp increase in the abnormal kidney function incidence with age.
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