McCarthy AM, Ehsan S, Appel S, et al. - Researchers examined risk factors for advanced breast cancer within 2 years of a negative mammogram. A total of 293,520 negative mammograms conducted from 2006 to 2015 among 74,736 women, were included. There were 1,345 breast cancers, of which 357 were advanced (26.5%), and 988 (73.5%) were at an early stage. An elevated risk of both advanced and early-stage cancers was observed in relation to factors such as breast density, prior biopsy, and family history. A 40% higher risk of early-stage cancer only in year 2 was found in overweight and obese women. A 90% elevated risk of advanced cancer in year 1 was evident in obese women, and a 40% or greater increased risk in year 2 was identified in both overweight and obese women. Findings revealed an association between a higher BMI and an advanced breast cancer diagnosis within 2 years of a negative mammogram.