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Risk factors associated with prolonged intestinal colonization of ESBL-producing Enterobacteriaceae – A prospective cohort study

Infection and Drug Resistance Sep 01, 2019

Ljungquist O, et al. - In this study, potential risk factors for prolonged intestinal colonization with β-lactamase-producing Enterobacteriaceae (EPE) were investigated. In addition, an analysis was performed to determine if adequate information about being infected or colonized by antibiotic-resistant bacteria is provided to patients. Researchers recruited patients with a positive clinical EPE culture from urine, blood, or feces in a region in the south of Sweden, and obtained selective EPE fecal cultures at least 3 months after the initial positive culture. The prevalence of any EPE in the follow-up fecal sample defined prolonged intestinal colonization. In this prospective cohort study, the investigators observed prolonged intestinal colonization with EPE in independent correlation with urological intervention within 6 months and a history of EPE infection. In contrast, they noted a decreased risk of prolonged intestinal colonization with EPE in correlation with travel to Africa and/or Asia within 2 years. As there were about 50% of patients who had inadequate knowledge of EPE infection or colonization before being approached by researchers, there seemed to be a room for improvement when it comes to patient information regarding EPE to decrease of spread.

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