George JC, et al. - Researchers determined the incidence and risk factors of rapid correction and osmotic demyelination in a retrospective cohort of 1490 patients admitted with serum sodium <120 mEq/L to seven hospitals in the Geisinger Health System from 2001 to 2017. Serum sodium increase of >8 mEq/L at 24 hours was defined rapid correction. Manual chart review of all available brain magnetic resonance imaging reports was used to determine osmotic demyelination. The occurrence of rapid correction was documented in 41% of patients presenting with severe hyponatremia. A documented episode of rapid correction was reported in nearly all patients with incident osmotic demyelination.