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Risk factors and outcomes for delayed kidney graft function in simultaneous heart and kidney transplant recipients: A database analysis

American Journal of Transplantation Feb 14, 2021

Parajuli S, Karim AS, Muth BL, et al. - Researchers aimed at determining the risk factors and outcomes for kidney delayed graft function (K‐DGF) in simultaneous heart and kidney (SHK) transplant recipients, using the OPTN/UNOS database. They analyzed a total of 1,161 SHK transplanted between 1998 and 2018, of which 311 (27%) were in the K‐DGF (+) group and 850 in the K‐DGF (‐) group. Multivariable analysis suggested that the history of pretransplant dialysis was significantly linked with the development of K‐DGF, as was donor death from cerebrovascular accident and longer cold ischemia time of either organ. Increased mortality and death censored kidney graft failure were identified among SHK recipients with K‐DGF in the multivariable analysis. Similar to kidney‐only recipients, worse outcomes were observed among SHK recipients in correlation with iK‐DGF. The risk of K‐DGF and the linked detrimental effects may reduce with performing careful matching of recipients and donors, as well as peri‐operative management.

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