Jeffers KW, Shah SA, Calvert DD, et al. - In this study, the outcomes of anterior cruciate ligament (ACL) reconstruction using quadrupled hamstring (QH) autograft in a cohort of National Collegiate Athletic Association (NCAA) Division I football players were explored. Between 2001 and 2016, a retrospective analysis was conducted on NCAA Division I football players at a single institution who had transtibial ACL reconstruction using QH autograft. From 2001 to 2016, 34 players had QH autograft ACL reconstruction. As per the findings, 29 players achieved a return to play (RTP). The data exhibited that QH indicated an ACL re-injury rate and RTP similar to previously published predominantly BTB ACL re-injury data in elite athletes. This research indicates that QH autograft may be a viable option for elite athletes.