Uffen JW, van Goor H, Reitsma J, et al. - Development was the quick Sequential Organ Failure Assessment (qSOFA) was performed to determine patients with infection with increased risk of dying from sepsis in non-intensive care unit settings, like the emergency department (ED). The initiation of appropriate therapy may be triggered by an abnormal score leading to reduction in the risk. Researchers here performed a retrospective analysis on data from a large observational cohort of 3,178 consecutive patients with suspected infection with the aim to determine the risk of a treatment paradox: the effect of a strong predictor for mortality will be reduced if that predictor also acts as a trigger for initiating treatment to prevent mortality. Researchers here examined the influence of baseline qSOFA on treatment decisions within the first 24 hours after admission in order to evaluate the existence of a treatment paradox. Findings suggest that a qSOFA ≥ 2 was linked with more intensive treatment in ED patients with suspected infection. This could result in inappropriate prediction of 30-day mortality due to the presence of a treatment paradox.