Retinol/inflammation affect stemness and differentiation potential of gingival stem/progenitor cells via Wnt/β-catenin
Journal of Periodontal Research Mar 08, 2019
El-Sayed KMF, et al. - Data were estimated to analyze the impact of retinol and periodontal inflammatory cytokines (IL-1β/TNF-α/IFN-γ) on pluripotency and proliferative characteristics of gingival mesenchymal stem/progenitor cells (G-MSCs). Researchers noted G-MSCs like CD14−, CD34−, CD45−, CD73+, CD90+, CD105+ exhibiting mesenchymal stem/progenitor cells' hallmarks, colony-forming units (CFUs), and multilineage differentiation potential. They observed the prominent presence of Nanog in the inflammatory and retinol group. They suggested the activation of the Wnt/β-catenin pathway, affecting G-MSCs’ pluripotency, proliferation, and differentiation due to controlled short-term inflammatory/retinol.
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