Corgiolu S, et al. - This pilot resting state (RS) functional connectivity magnetic resonance imaging (fcMRI) study was carried out in order to identify the eventual functional connectivity alteration that could reflect hepatitis C virus (HCV) related cognitive performance degradation. The inference drawn was that RS fcMRI could aid in comprehending the interactions between human immunodeficiency virus (HIV) and HCV co-infection. Findings also disclosed the synergic effects of HCV in HIV-related brain functional modification.