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Response to omalizumab in Black and White patients with allergic asthma

The Journal of Allergy and Clinical Immunology: In Practice Jul 25, 2021

Szefler SJ, Jerschow E, Yoo B, et al. - This post hoc analysis was conducted to estimate response to omalizumab in moderate-to-severe asthma patients of Black and White race in North America. From placebo-controlled (EXTRA)/single-armed (PROSPERO) omalizumab studies, data were obtained. Study sample consisted of 631 White/176 Black patients from EXTRA and 567 White/130 Black patients from PROSPERO. Placebo-corrected alteration in FEV 1 and Asthma Quality of Life Questionnaire (AQLQ) was estimated by racial group, using an analysis of covariance model. Findings revealed that omalizumab conferred similar improvements in exacerbations, FEV 1 , and AQLQ between Black and White patients suffering from moderate-to-severe asthma.

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