Ogata H, Yamazaki Y, Tezuka Y, et al. - To determine hyperaldosteronism-specific histopathologic renal changes, researchers herein compared kidney biopsy specimens of 19 cases with unilateral hyperaldosteronism vs 22 autopsy renal cases of estimated glomerular filtration rate-matched essential hypertension without nephropathy or endocrine disorders. Significantly higher mineralocorticoid receptor as well as 11β-hydroxysteroid dehydrogenase type 2 were detected in renal tubules of hyperaldosteronism, which could lead to enhancement of in situ aldosterone impacts in hyperaldosteronism kidneys. Significantly more marked interstitial fibrosis was found in hyperaldosteronism. There was also a significantly higher proportion of segmental glomerulosclerosis in hyperaldosteronism. In addition, significantly more pronounced arteriolar hyalinization was identified, particularly at efferent arterioles in hyperaldosteronism. Overall, hyperaldosteronism was associated with more pronounced whole renal damages. Also, early intervention using mineralocorticoid receptor antagonists or blockers could potentially be clinically significant.