Kade G, et al. - In patients with septic shock and AKI, researchers assessed the effect of continuous veno-venous hemodialysis (CVVHD) using high cutoff (HCO) hemofilters on the removal of procalcitonin (PCT), and other inflammatory markers. They evaluated PCT, native C-reactive protein (CRP) and cytokines (interleukin-1β, interleukin-6, interleukin-12, interleukin-17, tumor necrosis factor-α) in serum and effluent from patients, both before as well as after the 24-h HCO-CVVHD. Significantly lower serum concentrations of PCT, CRP and selected cytokines were detected post-HCO-CVVHD. PCT monitoring during HCO-CVVHD showed less utility, in contrast to the native CRP, as it indicated the clearance of this marker and anti-inflammatory efficacy of the method.