Niiranen TJ, et al. - In 2119 Framingham Offspring Cohort participants (mean age, 60 years; 57% women), researchers determined the prevalence and prognostic significance of mismatch between pulse pressure and arterial stiffness. They recorded carotid-femoral pulse wave velocity (CFPWV) and central pulse pressure (CPP) and defined 4 groups based on the values (categorized as high/low based on ≥age- and sex-specific median values). Cardiovascular disease (CVD) events were reported during the follow-up. They noted discordant CPP and CFPWV status in 832 of 2119 (39%) participants at baseline. Low CPP and high CFPWV were detected in 417 and high CPP and low CFPWV in 415 at baseline. Overall, findings revealed a common prevalence of pulse pressure-arterial stiffness mismatch in the community. A possible modifying impact of CFPWV on the link between CPP and CVD risk was also suggested. Those with elevated CPP and CFPWV had the greatest risk.