Dalrymple KV, et al. - In this contemporary large prospective cohort study with extensive maternal/childhood phenotyping and a high prevalence of maternal overweight/obesity, researchers analyzed associations of maternal early pregnancy (15 weeks' gestation) body mass index (BMI), overweight/obesity, and plasma biomarkers of obesity, inflammation, insulin resistance, and placental function with childhood BMI and adiposity measurements by linear regression, with appropriate adjustment. in the Screening for Pregnancy Endpoints (SCOPE) study, New Zealand, BMI z-score, sum of skinfold thicknesses, body fat percentage, and waist, arm, and hip circumferences were evaluated in 1173 six-year-old children of nulliparous pregnant women. Independent connections of maternal early pregnancy BMI with childhood BMI and adiposity were found in this analysis. Similar links with placental growth factor have been noted, which may mean a role for placenta function in childhood obesity risk developmental programming. There was no association between metabolic or inflammatory maternal biomarkers and childhood obesity.