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Relationships between retinopathy of prematurity without ophthalmologic intervention and neurodevelopment and vision at 2 years

Pediatric Research Oct 27, 2021

Brumbaugh JE, Bell EF, Hirsch SC, et al. - Compared with children without retinopathy of prematurity (ROP), those with ROP stage ≤3 without intervention had no adverse neurodevelopmental outcomes at 2 years’ corrected age but had an increased incidence of strabismus.

  • In this secondary analysis of a randomized trial assessing the impacts of myo-inositol on ROP in the NICHD (National Institute of Child Health and Human Development) Neonatal Research Network, 506 children were included.

  • Among participants, there was absence of ROP in 173 (34%), presence of ROP stage ≤3 without intervention in 262 (52%), and ROP with intervention in 71 (14%).

  • In terms of motor, cognitive, or language scores, no difference was found between children with ROP stage ≤3 without intervention and children without ROP.

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