Zhang Q, et al. - Whether left ventricular thrombus (LVT) formation is associated with one-year major adverse cardio-cerebrovascular events (MACCE) in patients with anterior acute ST-segment elevation myocardial infarction (ant-AMI) treated by primary percutaneous coronary intervention (PPCI) was investigated. Participants were 1,488 consecutive patients with ant-AMI, who were examined for the incidence of MACCE within one year after AMI and the disappearance of thrombosis. According to findings, LVT was identified as an independent predictor of one-year MACCE events for patients with ant-AMI treated by PPCI. These results suggest the potential of VKA treatment in the therapeutic range (INR≥2) to attenuate MACCE risk and encourage disappearance of thrombus.