Yang J, Gwini SM, Beilin LJ, et al. - Given increased aldosterone in the setting of low renin is predictive of incident hypertension among normotensive adults, researchers herein explored this association among adolescents and young adults. They studied data from the offsprings (Gen2) of females enrolled during pregnancy into the Raine Study (population-based birth cohort), who underwent blood pressure (BP) measurements and had blood samples at age 17 years (N=871) and age 27 years (N = 758). At 17 years, similar median aldosterone levels but significantly lower direct renin level was detected in females, and thus, they had a higher aldosterone-to-renin ratio (ARR) vs males. Post-adjustment for alcohol intake, physical activity, and body mass index, there was a significant link between ARR and systolic BP in 17 years males. There was no such correlation in females at 17 years. Females demonstrated a significant correlation of ARR at 17 years with both systolic and diastolic BP at 27 years; this was not seen in males. Findings revealed sexually dimorphic association between the ARR and BP in 17 and 27 years participants, which is indicative of the likely usefulness of ARR (calculated from the plasma aldosterone level and direct renin level) as an instrument for BP prediction as well as evaluation in young people, but gender-specific interpretation is needed.