Chan KI, et al. – This study was designed not only to report the status of most common gene mutations in non–small cell lung carcinoma (NSCLC) in Macao but also to investigate the association between each gene mutation and clinicopathologic features and survival. It was noted that EGFR mutation occurred frequently in the female never smoke patients with NSCLC whereas KRAS mutation was more common in old patients. Negative MET protein expression could be utilized as a negative predictive marker of MET amplification. Data reported that MET protein expression was an independent prognostic factor for NSCLC.