Relation of minor electrocardiographic abnormalities to cardiovascular mortality
The American Journal of Cardiology Feb 15, 2019
Hari KJ, et al. - Since inconsistent reports exist regarding the prognostic significance of minor electrocardiographic (ECG) abnormalities—which are common findings in clinical practice—researchers investigated whether this inconsistency is due to the traditional focus on examining their prognostic significance as a binary variable (ie, presence vs absence of any abnormality) ignoring the number of abnormalities. For this purpose, they examined 6,467 participants (mean age: 59 years; 53% women) from the Third National Health and Nutrition Examination Survey who were free of baseline cardiovascular disease (CVD) and major ECG abnormalities. They assessed ECG abnormalities as well as CVD mortality. They found a marginal association of the presence of at least one minor ECG abnormality with an increased risk of CVD mortality. However, a dose-response link was evident for the association with CVD mortality, as the number of ECG abnormalities increased. Overall, considering the number, not only the mere presence of minor ECG abnormalities, was recommended to understand the prognostic significance of these common findings.
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