Kwok CS, Lundberg G, Al-Faleh H, et al. - Using the National Inpatient Sample database, researchers analyzed US adults with a diagnosis of acute coronary syndrome (ACS) in order to determine the prevalence of frailty, temporal shifts over time, and its relation to treatments and clinical outcomes in these patients. Based on ICD-9 codes, a validated Hospital Frailty Risk Score was used to assess frailty risk, with the cutoffs <5, 5-15 and >15 for low (LRS), intermediate risk and high risk (HRS) frailty scores, respectively. They found that ACS patients were commonly at risk of frailty. Also, the increasing prevalence of frailty was reported in these patients over time. Findings also revealed the link of frailty with differential treatment strategies and results during hospitalization. Those with lowest frailty risk scores constituted the greatest proportion of patients treated with PCI. A significant rise in bleeding complications, vascular complications, in-hospital stoke and in-hospital mortality was observed on comparing HRS to LRS. To reduce the risk of adverse consequences, increased awareness may aid frailty-tailored care.