Rehabilitation of cognitive deficits poststroke: Systematic review and meta- analysis of randomized controlled trials
Stroke Feb 08, 2022
According to findings of this systematic review and meta-analysis, there exists some evidence to back multiple component interventions, physical activity interventions, and noninvasive brain stimulation improving cognitive function after stroke.
By exploring five databases from inception to August 2019, researchers identified a total of 64 eligible randomized controlled trials (n=4,005 participants) of rehabilitation interventions for people with stroke when compared with other active interventions or standard care where cognitive function was an outcome.
Improvements in general cognitive functioning (MD, 1.56) and memory (standardized MD, 0.49) were achieved with multiple component interventions vs standard care.
Physical activity interventions brought about improvements in neglect (MD, 13.99) and balance (MD, 2.97) than active controls.
There was an impact of noninvasive brain stimulation on neglect (MD, 20.79) and functional status (MD, 14.02) relative to active controls.
A significant impact on cognitive function was not exerted by cognitive rehabilitation (MD, 0.37) or occupational-based interventions (MD, 0.45), compared with standard care.
The observations call for cautious interpretation due to the overall moderate to high risk of bias, heterogeneity of interventions, and outcome measures across studies.
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