Lazo-Porras M, Bernabe-Ortiz A, Ruiz-Alejos A, et al. - In this cohort study, researchers estimated the prevalence of prediabetes according to various definitions, assessed regression to normal glucose levels and progression towards T2DM, and determined regression and progression factors across four different geographic settings in Latin America. According to the World Health Organization (WHO), American Diabetes Association (ADA), and National Institute for Health and Care Excellence (NICE) definitions, prediabetes, T2DM and normal glucose levels were defined. Age, BMI, and insulin resistance were factors linked to regression to normal glucose levels and progression to diabetes. Investigators discovered that the figures depended on the definitions used (WHO, ADA, NICE), but about half of those with prediabetes had normal glucose 2.2 years later and about one fifth to one-tenth of those with diabetes had progressed. Findings suggested that regression from prediabetes back to euglycemia was much more common than diabetes progression.