Wang Y, Zhao Y, Zou L, et al. - The incidence of early-onset group B Streptococcus (GBS) neonatal sepsis (EOGBS) can be reduced via implementation of prevention strategies. Rates of GBS colonization and infection vary among regions within China. China has not adopted a unified prevention strategy. Researchers aimed at assessing strategies to reduce EOGBS in China via developing models to estimate residual EOGBS rates with intrapartum antibiotic prophylaxis in infants ≥ 35 weeks’ gestation in risk factor-based and antepartum screening-based strategies. Three regions of China (A: Xiamen of Fujian province, B: Shanghai and C: Liuzhou of Guangxi province) were assessed for maternal GBS colonization rates and EOGBS incidence using published data. Regions A, B and C were estimated to have GBS colonization and attack rates of 21.6%, 11.7% and 6.1% and 1.79, 1.79 and 0.58 per 1,000 live births, respectively. Observations suggest the possible necessity for different strategies for preventing EOGBS in different regions of mainland China. Most appropriate being screening strategies in regions with higher attack rates, even with moderate levels of maternal GBS colonization. Risk factor strategies that lower morbidity by at least one-third may suffice in areas with low attack rates.