Capdevila M, et al. - In this present study, the authors show that ICU physicians should perform a pivotal role in developing regional anesthesia techniques that are underused in critically ill patients despite the proven facts in perioperative and long-term pain, organ dysfunction, and postsurgery patient health-related quality of life improvement. In ICU surgical/trauma patients, promoting regional anesthesia/analgesia can undoubtedly limit the risk of complications, ICU/hospital stay, and improve patient's outcome. As per the outcomes, the use of regional anesthesia permits a high dose opioid use limitation which is mandatory and should be considered as feasible and well tolerated in ICU.