Pill SG, McCallum J, Tolan SJ, et al. - Preclinical evaluations demonstrated a higher rate of osseous integration for the open-architecture design of the Healicoil Regenesorb anchor than the closed-threaded design of the Twinfix (Smith & Nephew). This study was attempted to explore these 2 anchors with different architecture and materials to ascertain their impact on osseous integration and clinical outcomes after rotator cuff repair. Researchers conducted a prospective randomized controlled trial between 2014 and 2019 including a total of 64 patients (39 females, 25 males) with an average age of 58.7 years who had undergone arthroscopic rotator cuff repair by one of 4 board-certified, fellowship-trained surgeons were randomized to receive Healicoil Regenesorb (PLGA/ß-TCP/Calcium Sulfate) or Twinfix Ultra HA (PLLA/HA) anchors. The rate of healing and patient-reported outcomes were similar between the Twinfix and Healicoil anchor groups, despite differences in material and anchor architecture. At 2 years, the rate of osteointegration was the same.